Endocrine Abstracts

Introduction: The obstructive sleep apnea syndrome (OSAS) has a well-documented association with increase cardiovascular morbidity and mortality. The patients with OSAS have a high prevalence of hypertension and the OSAS may present similar to a pseudo-pheochromocytoma (PPH). We report two cases with PPH caused by OSAS; a common medical condition which is less recognized as a cause of raised catecholamines.Observations: Case 1: 54 year-old man had a hist...

Introduction: Neurofibromatosis 2 (NF2) is a rare genetic disease characterized by the development of multiple schwannomas and meningiomas. It has a very variable phenotype but the most common type of tumor to develop is the vestibular schwannoma. We report clinical case of NF2 which has been revealed by hypertension.Observation: We report the case of a 25-year-old woman referred to our institution for evaluation of hypertension. She had no family histor...

Introduction: Erectile dysfunction (ED) is quite common. It poses a problem of diagnosis and management given the multiplicity of contributing factors and etiologies that can sometimes be unrecognized.Observations: We report 3 observations of patients followed for insulin-requiring diabetes. The average age was 51. They had ED for 3.5 years on overage. The clinical examination of our patients showed obesity or weight excess. The impact assessment of diab...

Introduction: Pituitary adenoma has been exceptionally reported in Down’s syndrome (DS). We report the case of a 23 year-old patient diagnosed with Down’s syndrome, who was admitted to the Endocrinology Department for a macroprolactinoma.Case report: A 23 year-old woman, diagnosed with DS, presented with acute headaches and diplopia. She had no history of trauma, and physical examination showed signs of damaged third and sixth cranial nerves, a...

Introduction: Adverse events among patients treated for tuberculosis are under-researched and underreported. Two cases of hypothyroidism induced by tuberculosis drug were reported in two older women.Observations: Case 1: A 69-year-old male, complaining of asthenia and weight gain. He had been treated for his pulmonary tuberculosis during the past 6 months with a quadritherapy antituberculous regimen consisting of Rifampicin, isoniazid, ethambutol, pyrazi...

Introduction: Pituitary tumors are the most frequent intracranial neoplasm. However metastases in this location are rare and uncommon presentation of systemic malignancy. The clinical and radiologic features of most pituitary metastases can be characteristic and evocative but in no case pathognomic. The diabetes insipidus is the most common clinical manifestation of the disease. We report here four cases of pituitary metastases of lung cancer in an elderly patients mimiking pi...

Introduction: Hyperthyroidism produce changes in cardiac contractility, blood pressure, and systemic or pulmonary vascular resistance. In almost all cases these cardiovascular changes are reversible when the underlying thyroid disorder is recognised and treated. Pulmonary hypertension (PAH) has been associated with hyroid dysfunction, but primaraly with hyperthyroidism. The vast majoity of patients with this form of PAH are usually older with toxic multinoduar goitre. The aim ...

Introduction: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that predominantly affects women. The coexisting Klinefelter’s syndrome (47,XXY) and SLE was rare.Observations: We report a case of a middle-aged male had SLE discovered by arthralgia. He presented hypogonadism. Hormonal examinations showed a low serum testosterone level (0.3 ng/ml), and high follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels (24.1 ...

Background: Antithyroid drugs (ATD) are indicated as first intension in the treatment of Graves’disease (GD). Only two molecules are marketed in Tunisia: Benzylthiouracil (BTU) and Methimazole (MMI). There is still no clear conclusion about the choice of appropriate drug. Our objective was to compare the MMI treatment with the BTU in terms of efficacy and adverse effects (AEs).Methods: It’s a retrospective study. We studied patients with a firs...

Introduction: Precocious puberty (PP) is the development of secondary sexual characteristics before the age of 8 years in girls and beforethe age of 9 years in boys. Central PP has an idiopathic origin in upto 95% of girls while in up to 50% of males. The diagnostic and the management of PP can beparticularly complex. Here we describe cases of two sisters having central PP with different presentation and evolution.Observations: First case: A 13-years-old...